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为了研究各种胰岛素类似物的结构特征和B链羧端肽段的运动特征,在对各种胰岛素类似物广泛的结构比较基础上,梁栋材等人提出了胰岛素分子与其受体分子相互作用的两性表面,阐述了胰岛素分子在与受体结合过程中B链羧端肽段的运动及构象变化特征.Derewenda等人对B29-Al交联胰岛素的研究结果表明,由于B29-Al肽键的联结限制了B链羧端的运动,导致胰岛素失活.其它B链羧端的人变异胰岛素和修饰胰岛素的研究工作
In order to study the structural characteristics of various insulin analogs and the motility characteristics of the B-terminal carboxy-terminal peptide, Liang et al. Proposed an amphipathic interaction between insulin molecules and their receptor molecules based on a broad structural comparison of various insulin analogs Surface, and elucidates the motility and conformational changes of the B-terminal carboxy-terminal peptide in the process of insulin receptor binding.Derewenda et al’s study on the B29-Al cross-linked insulin showed that due to the binding of the B29-Al peptide bond Movement of the carboxy-terminal side of the B chain leads to inactivation of insulin Other human variants of the B-chain at the carboxy terminus Insulin and modified insulin Research work