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目的观察诺氟沙星预防鼠疫的效果。方法参照《中华人民共和国国家药典》成人剂量,用施新猷的动物折算系数法换算成家兔每日用药剂量60 mg／kg,分2次以灌胃法给实验3组动物预防用药3 d,第4天分别用含菌1．5×107个／只剂量感染实验3组和对照组动物。实验3组动物继续用药6 d后停药,观察诺氟沙星预防鼠疫的效果。结果实验3组动物存活率100％,对照组动物存活率为0。结论诺氟沙星预防实验感染动物鼠疫效果显著。
Objective To observe the effect of norfloxacin on the prevention of plague. Methods According to the “National Pharmacopoeia of the People’s Republic of China” adult dose, with the animal husbandry Xinxian conversion coefficient method translated into the daily dose of rabbit 60 mg / kg, 2 times by gavage to the experimental group 3 animal preventive medication 3 d, 4 days were infected with bacteria containing 1.5 × 107 / only experimental group 3 and control animals. The animals in experiment 3 were discontinued after 6 days of treatment, and the effect of norfloxacin in preventing plague was observed. Results The survival rate of animals in experiment 3 group was 100%, while that in control group was 0. Conclusion Norfloxacin has significant effect in preventing experimental plague infection in animals.