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目的分析妊娠期高血压疾病(PIH)妇女外周血调节性T细胞和辅助性T细胞表达变化。方法连续选择近期住院确诊的PIH妇女27例(PIH组),入选对象均接受了外周血调节性T细胞(CD 4+CD 2+5 Treg和CD 4+CD 2+5Foxp3+Treg)和辅助性T细胞(CD 3+、CD 4+、CD 8+、CD 4+/CD 8+)检测,并与同期住院正常怀孕产妇(对照组,20例)相同测试结果进行比较。结果 调节性T细胞数据中,PIH组血清CD 4+CD 2+5 Treg和CD 4+CD 2+5 Foxp3+Treg水平明显低于对照组(P均<0.05～0.01)。辅助性T细胞中,PIH组血清CD 4+/CD 8+表达水平明显高于对照组,而CD 8+表达水平则显著低于对照组(P均<0.05～0.01)。结论 PIH患者存在明确的外周血调节性T细胞和辅助性T细胞异常表达。
Objective To analyze the expression of regulatory T cells and helper T cells in peripheral blood of women with gestational hypertension (PIH). Methods A total of 27 PIH women were selected as the hospitalized PIH patients consecutively. All the patients were enrolled in this study. All of the patients were treated with peripheral blood Tregs (CD 4 + CD 2 + 5 Tregs and CD 4 + CD 2 + 5 Foxp 3 + Tregs) T cells (CD3 +, CD4 +, CD8 +, CD4 + / CD8 +) were detected and compared with the same test results in the same period of hospitalized normal pregnant women (control group, 20 cases). Results In Treg data, the levels of CD 4 + CD 2 + 5 Treg and CD 4 + CD 2 + 5 Foxp 3 + Treg in PIH group were significantly lower than those in control group (all P <0.05-0.01). The level of CD 4 + / CD 8+ in PIH group was significantly higher than that in control group, while the level of CD 8+ in auxiliary T cells was significantly lower than that in control group (all P <0.05-0.01). Conclusion There is a clear abnormal expression of peripheral blood regulatory T cells and helper T cells in PIH patients.