本文论述了应用反义寡核苷酸可防止因血管平滑肌细胞增生和迁移所造成的血管成形术后再狭窄,如c-myb基因、c-myc基因、增生细胞核抗原、非肌肉型肌球蛋白重链等的反义寡核苷酸均能抑制血管平滑肌细胞的这种增生和迁移。本文还讨论了进一步提高反义寡核苷酸效力的措施,包括促进反义寡核苷酸的吸收、亲合力、特异性及稳定性等。 This article discusses the use of antisense oligonucleotides to prevent post-angioplasty restenosis caused by vascular smooth muscle cell proliferation and migration, such as the c-myb gene, c-myc gene, proliferating cell nuclear antigen, non-myosin Antisense oligonucleotides such as heavy chains inhibit this proliferation and migration of vascular smooth muscle cells. This article also discussed the further improvement of antisense oligonucleotide efficiency measures, including the promotion of antisense oligonucleotide absorption, affinity, specificity and stability.