多胺类似物是一类研发中的新型抗肿瘤药物。在肿瘤细胞内,多胺类似物通过干扰正常多胺代谢耗竭肿瘤快速生长必需的多胺成分、影响DNA结构和功能、调节肿瘤相关基因表达水平、改变细胞周期和诱导细胞凋亡等途径发挥抗肿瘤效应。本文就多胺类似物及其抗肿瘤的作用机制作一综述。 Polyamine analogs are a new class of antineoplastic drugs under development. In tumor cells, polyamine analogues exert their anti-tumor effects by interfering with normal polyamine metabolism and depleting the polyamine components required for rapid tumor growth, affecting DNA structure and function, regulating tumor-related gene expression, altering cell cycle and inducing apoptosis Tumor effect. This article reviews the mechanisms of polyamine analogs and their anti-tumor effects.