糖尿病肾病是糖尿病常见并发症，早期诊断困难。本文着重探讨红细胞钠－锂逆向转运活性在糖尿病肾病早期诊断中的价值、存在的争议及产生争议的可能原因分析。同时介绍了红细胞钠－锂逆向转运的生理学特征和测定方法，以及它与高血压、高脂血症和胰岛素抵抗的关系 Diabetic nephropathy is a common complication of diabetes, early diagnosis difficult. This article focuses on the value of erythrocyte sodium-lithium reverse transport activity in the early diagnosis of diabetic nephropathy, the controversy and possible causes of controversy. At the same time introduced the red blood cell sodium - lithium reverse transport physiological characteristics and determination methods, and its relationship with hypertension, hyperlipidemia and insulin resistance