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作者报导204例接受速尿的住院患者(男122例,女82例,平均年龄69.6岁)中,有154例(75％)发生药物诱致生化异常。每例患者的平均异常项数为3.04个。这些生化异常中有71％是明确或可能由速尿引起的。与速尿有关的最常见异常是:低氯血症40％,高尿酸血症40％,低钠血症28％,高碳酸血症28％,低钾血症27％,低钙血症21％和低血糖20％;26％(52/199)的患者发生药物诱致高钾血症。药物诱致生化异常的发生率与患者年龄、肾功能损害、给药种数和速尿剂量成正比,与体重成反比。接受速尿时补
The authors reported 154 drug-induced biochemical abnormalities in 154 (75%) of 204 hospitalized patients receiving furosemide (122 men and 82 women, mean age 69.6 years). The average number of anomalies per patient was 3.04. 71% of these biochemical abnormalities are specific or may be caused by furosemide. The most common abnormalities associated with furosemide are: 40% of hypochlorosis, 40% of hyperuricemia, 28% of hyponatremia, 28% of hypercapnia, 27% of hypokalemia, and hypocalcaemia 21 % And hypoglycemia 20%; 26% (52/199) of the patients with drug-induced hyperkalemia. The incidence of biochemical abnormalities induced by drugs is directly proportional to patient age, impaired renal function, number of dosing and dose of furosemide, and is inversely proportional to body weight. When receiving furosemide fill