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ESAT- 6即 6k Da早期分泌性抗原性靶 ,是从结核杆菌短期培养滤液 (ST- CF)中纯化分离出的一种低分子量分泌性蛋白 ,具有较强的细胞免疫活性 ,在抗结核感染的免疫回忆应答中起重要作用 ;由于编码 ESAT- 6的基因在卡介苗 (BCG)各菌株中缺乏 ,ESAT- 6可望成为人和动物结核病的特异性诊断试剂、抗结核亚单位疫苗的组分和 DNA疫苗的候选目的抗原
ESAT-6 is a 6kDa early secretory antigenic target. It is a low-molecular-weight secretory protein purified from Mycobacterium tuberculosis short-term culture filtrate (ST-CF) and has a strong cellular immune activity against tuberculosis Immune response. Since ESAT-6-encoding genes are absent in Bacillus Calmette-Guerin (BCG) strains, ESAT-6 is expected to become a specific diagnostic reagent for human and animal tuberculosis. The components of the anti-TB subunit vaccine And DNA vaccine candidate antigen of choice