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在应用抗痫药物(AED)治疗癲痫的过程中,其疗效常受个体差异、对长期服药的合作和药物产生的耐受性、毒副作用等因素的影响。许多癫痫患者因长期甚至接受多种药物治疗但效果不显著而被认为是“难治的”癫痫。我们对本院癲痫专病门诊随访的这类患者221例,在监测血药浓度下调整药物治疗的情况进行总结和回顾。
In the application of antiepileptic drugs (AED) in the treatment of epilepsy, its efficacy is often affected by individual differences, the long-term medication cooperation and drug resistance, side effects and other factors. Many epilepsy patients are considered as “refractory” epilepsy due to the long-term or even multi-drug treatment but the effect is not significant. 221 cases of these patients were followed up in the outpatient department of our hospital for epilepsy. We summarized and reviewed the adjustment of the drug treatment under the monitoring of plasma concentrations.