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观察了静脉注射ＣａＣｌ２对发热家兔的降温作用与血浆和脑脊液（ＣＳＦ）中Ｎａ＋，Ｃａ＋＋含量及ＣＳＦ中Ｎａ＋／Ｃａ＋＋比值变化的关系。结果发现内毒素（ＥＴ）性发热家兔组血浆和ＣＳＦ中的Ｃａ＋＋含量明显低于正常家兔组，ＣＳＦ中的Ｎａ＋／Ｃａ＋＋比值明显高于正常家兔组。静脉注射ＣａＣＩ２引起降温效应的家兔组，除了血浆中Ｃａ＋＋含量升高外，而且ＣＳＦ中的Ｃａ＋＋含量升高到正常水平，同时使Ｎａ＋／Ｃａ＋＋比值降低到接近于正常家兔组的水平。这提示，静脉注射ＣａＣｌ２使ＥＴ性发热家兔的体温降低，可能是通过增加脑内的Ｃａ＋＋含量，降低Ｎａ＋／Ｃａ＋＋比值而实现的。
The relationship between the cooling effect of CaCl2 on rabbits with fever and the content of Na + and Ca ++ in plasma and cerebrospinal fluid (CSF) and the ratio of Na + / Ca ++ in CSF was observed. The results showed that the content of Ca ++ in plasma and CSF of rabbits with endotoxin-induced fever was significantly lower than that of normal rabbits, and the ratio of Na + / Ca ++ in CSF was significantly higher than that in normal rabbits. In addition to the increase of Ca ++ content in plasma, Ca ++ content in CSF increased to normal level in rabbits in intravenous injection CaCl2-induced cooling effect, meanwhile Na + / Ca ++ ratio decreased to close to that of normal rabbits. This suggests that the intravenous injection of CaCl2 to ET-induced fever in rabbits decreased body temperature, may be increased by increasing the content of brain Ca ++, Na + / Ca ++ ratio to achieve reduction.