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观察大鼠脑缺血后不同时点实施低温对脑梗塞的影响，对比观察选择性低温和全身性低温的疗效差异。Ａ组维持正常脑温；Ｂ组、Ｃ组分别于缺血即刻和再灌流即刻实施头颅选择性低温；Ｄ组于缺血即刻实施全身性低温；Ｅ组于缺血即刻头颅选择性低温后快速复温。各组低温时间均为３ｈ。大鼠局灶性脑缺血３ｈ再灌流４８ｈ后进行神经功能评分、脑血流测定和病理检查。结果表明，与Ａ组比较，Ｂ组及Ｃ组动物脑梗塞体积明显缩小，动物神经症状也明显改善；Ｄ组脑梗塞体积也明显缩小，但动物神经症状无显著改善。Ｅ组与Ｂ组比较各项指标无显著差异。提示缺血后低温能够降低脑梗塞体积，头颅选择性低温比全身性低温疗效好。
To observe the effect of hypothermia on cerebral infarction at different time points after cerebral ischemia in rats, and compare the curative effect between selective hypothermia and general hypothermia. A group maintained normal brain temperature; B group, C group were immediately carried out in the ischemic and reperfusion perfusion skull selective hypothermia; D group immediately in the implementation of systemic hypothermia; E group immediately after the onset of ischemic skull selective low temperature rapid Rewarming. Each group of low temperature time are 3h. After 3h and 48h after focal cerebral ischemia in rats, neurological function score, cerebral blood flow and pathological examination were performed. The results showed that compared with group A, the volume of cerebral infarction in group B and group C was significantly reduced and the neurological symptoms of animals were also significantly improved. The volume of cerebral infarction in group D was also significantly reduced, but no significant improvement was found in the neurological symptoms. There was no significant difference in each index between E group and B group. Tip hypothermia can reduce the volume of cerebral infarction, cranial selective hypothermia better than systemic hypothermia.