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目的:观察足三里穴位注射黄芪注射液对晚期胃癌患者肿瘤坏死因子(TNF-α)、白细胞介素(IL-6)、白细胞(WBC)及生活质量的影响。方法:将收治的66例晚期胃癌患者,以随机数字表法分为3组各22例,A组采用替吉奥、奥沙利铂加黄芪注射液足三里穴位注射治疗;B组采用替吉奥、奥沙利铂加生理盐水足三里穴位注射治疗;C组以单纯替吉奥加奥沙利铂治疗,对3组患者治疗前后相关指标及生活质量进行观察。结果:生活质量改善情况显示,治疗后提高率A组86.36%,B组59.09%,C组50.00%,3组比较,A组分别与B组、C组比较,差异均有统计学意义(P<0.05)。治疗后,A组WBC、TNF-α、IL-6等水平分别与B组及C组比较,差异均有统计学意义(P<0.05),B组WBC及IL-6分别与C组比较,差异均有统计学意义(P<0.05)。结论:晚期胃癌采取足三里穴位注射黄芪注射液辅助药物化疗方案治疗,可缓解化疗所致毒副作用,控制机体炎性反应,改善指标情况,利于患者顺利开展化疗,改善预后,值得临床运用。
Objective: To observe the effects of astragalus injection of Zusanli (ST36) injection on tumor necrosis factor (TNF-α), interleukin (IL-6), white blood cell (WBC) and quality of life in patients with advanced gastric cancer. Methods: Sixty-six patients with advanced gastric cancer admitted to our hospital were divided into three groups (n = 22 in each group) by random number table. Group A was treated with TIGO and oxaliplatin plus astragalus injection at points of Zusanli. Austria, oxaliplatin and saline injection Zusanli acupuncture points; C group with a simple for the treatment of oxgagau plus platinum, the 3 groups of patients before and after treatment related indicators and quality of life were observed. Results: The improvement of quality of life showed that the improvement rate after treatment was 86.36% in group A, 59.09% in group B and 50.00% in group C, and there was significant difference between group A and group B and group C (P <0.05). After treatment, the levels of WBC, TNF-α and IL-6 in group A were significantly lower than those in group B and group C, respectively (P <0.05). The levels of WBC and IL-6 in group B were significantly lower than those in group C The differences were statistically significant (P <0.05). Conclusion: The treatment of advanced gastric cancer with injection of astragalus injection at the point of Zusanli can ameliorate the toxic and side effects induced by chemotherapy, control the inflammatory reaction and improve the index of patients. It is beneficial to the patients to carry out chemotherapy and improve the prognosis well, which deserves clinical application.