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念珠菌是新生儿重症监护室(NICU)重要的病原体,它可通过感染播散引起脑膜炎,肾脏、脾或肝脓肿,眼内炎,骨髓炎及侵袭性皮肤炎,而血液感染是最常见形式。念珠菌血症的发生率逐年上升,尤其在NICU,占院内感染性疾病的15．8％。由于早产儿和低体重儿自身的内在特点,如T淋巴细胞数量的减少,中性粒细胞数量及功能的降低,皮肤结构的不成熟,表皮屏障的破裂等导致其相应的免疫功能低下,更容易发生侵袭性真菌感染。念珠菌
Candida is an important causative agent in the Neonatal Intensive Care Unit (NICU) that can cause meningitis, renal, splenic or hepatic abscesses, endophthalmitis, osteomyelitis and invasive dermatitis by disseminated infections, with bloodstream infections being the most common form. The incidence of candidaemia increased year by year, especially in the NICU, accounting for 15.8% of nosocomial infections. Due to the inherent characteristics of premature children and low birth weight children, such as the reduction of the number of T lymphocytes, the decrease of the number and function of neutrophils, the immature skin structure and the breakdown of the epidermal barrier, Invasive fungal infection prone. Candida