目的探讨多发性硬化(multiple sclerosis,MS)患者的抑郁情况及相关影响因素。方法采用汉密尔顿抑郁量表对55例确诊的MS患者及50例健康人进行调查,了解其抑郁的发生率并对相关影响因素进行多元logistic回归分析。结果 MS组患者抑郁发生率为40.0%,明显高于健康人(χ~2=9.835,P=0.002)。logistic回归分析显示,扩展残疾状况评分(EDSS)与抑郁相关(P=0.007,OR=2.060,95%CI:1.162~3.764);性别、年龄、病程、发作次数、是否有脑部病灶等因素与抑郁无明显相关性。结论 MS患者抑郁发生率很高,其抑郁的发生与患者神经功能缺损有关。MS患者的抑郁情况应受到重视。 Objective To investigate the depression and its related factors in patients with multiple sclerosis (MS). Methods The Hamilton Depression Rating Scale was used to investigate 55 confirmed MS patients and 50 healthy controls to find out the incidence of depression and multivariate logistic regression analysis of related factors. Results The incidence of depression in MS group was 40.0%, significantly higher than that in healthy people (χ ~ 2 = 9.835, P = 0.002). Logistic regression analysis showed that EDSS was associated with depression (P = 0.007, OR = 2.060, 95% CI: 1.162 ~ 3.764); gender, age, course of disease, number of seizures, brain lesions and other factors No significant correlation between depression. Conclusion The incidence of depression in MS patients is very high. The incidence of depression is related to the neurological deficits in patients. Depression in patients with MS should receive attention.