目的:研究卒中后抗抑郁药物的治疗对患者认知和肢体功能恢复的作用。方法:选取我院2003-04/2007-11脑卒中患者84例,随机分为两组,治疗组常规内科治疗脑卒中的基础上加用抗抑郁药物路优泰,并与安慰剂组做比较。结果:治疗组临床神经功能缺损评分明显优于对照组,抑郁状态明显好转,总有效率显著高于对照组。结论:对卒中后抑郁患者予抗抑郁药物治疗可促进执行功能的恢复。 OBJECTIVE: To study the effect of antidepressant therapy on cognitive recovery and limb function recovery after stroke. Methods: Eighty-four stroke patients in our hospital from 2003-04 / 2007-11 were randomly divided into two groups. The treatment group was given conventional antihypertensive drug Lutrutate on the basis of conventional medical treatment of stroke, and compared with placebo group . Results: The score of clinical neurological deficit in the treatment group was significantly better than that of the control group. The depression status was obviously improved and the total effective rate was significantly higher than that of the control group. Conclusion: Antidepressant treatment in post-stroke depression patients may promote the recovery of executive function.