目的:评价0.5%马来酸噻吗洛尔水剂治疗浅表型婴幼儿血管瘤(IH)的效果，并探讨Ln *an *bn *色彩模式分析瘤体颜色的可行性。n 方法:以2014年1月至2018年12月在浙江省人民医院整形外科接受0.5%噻吗洛尔水剂外敷治疗的符合入选标准的浅表型IH患儿为研究对象，对其资料进行回顾性分析。采用视觉模拟量表(VAS)评价疗效，VAS评分-100至0分表示差，1至49分表示一般，50至89分为良好，90至100分为优。采用国际照明委员会(CIE) Ln *an *bn *色彩模式数字化描述瘤体颜色变化，L值为亮度坐标值，a值为红绿坐标值，b值为黄蓝坐标值。对治疗前、后L、a、b变化(ΔL、Δa、Δb)采用配对n t检验，并对ΔL、Δa、Δb与VAS评分进行Pearson相关性分析。n 结果:共纳入25例患儿(30处瘤体)，包括头颈部13处，躯干9处，四肢8处。25例中男8例，女17例，年龄大于1个月且小于6个月。治疗后停药随访时(2～37个月)，VAS评价结果显示2处瘤体(6.7%)为一般，8处(26.7%)为良好，20处(66.7%)为优。头颈部、躯干、四肢3个部位疗效达到优的比例分别为69.2%(9/13)、66.7%(6/9)、62.5%(5/8)，差异无统计学意义(n χ2＝0.101, n P＝0.951)。治疗后L值升高了9.25±8.96，a值下降了4.68±11.08，b值下降了2.44±7.18，差异均有统计学意义(n t值分别为-8.383、3.763、2.813，n P值分别为<0.001、<0.001、0.006)。相关性分析显示ΔL值与VAS评分成正相关(n r＝0.616, n P<0.001)，Δa值与VAS评分成负相关(n r＝-0.640, n P<0.001)，Δb值与VAS评分不相关(n r＝-0.028, n P＝0.883)。n 结论:0.5%马来酸噻吗洛尔水剂可有效治疗浅表型IH。ΔL、Δa与VAS评分相关性良好，Ln *an *bn *色彩模式能较准确地反映瘤体颜色变化，可作为评价浅表型IH疗效的客观指标。n “,”Objective:To evaluate the efficacy of 0.5% timolol maleate aqueous solution in the treatment of superficial infantile hemangioma (IH) and explore the feasibility of Ln *an *bn * color system to assess the lesion color.n Methods:A retrospective analysis was conducted on the data of superficial IH who received 0.5% timolol aqueous solution and met the inclusion criteria in the Department of Plastic Surgery of Zhejiang Provincial People’s Hospital from January 2014 to December 2018. Visual Analogue Scale (VAS) was used to evaluate the efficacy. Therapeutic responses were graded as follow: poor (VAS score ranging from -100 to 0), fair (VAS score ranging from 1-49), good (VAS score ranging from 50-89) and excellent (VAS score ranging from 90 to 100). The lesion color was expressed in terms of the Commission Internationale de l’Eclairage(CIE) Ln *an *bn * color system, where L corresponds to the lightness, a to the red-green coordinate and b to the yellow-blue coordinate. Paired n t-test was used to evaluate the difference of L value, a value and b value (ΔL, Δa and Δb) before and after treatment respectively. Pearson correlation analysis was carried out between ΔL, Δa and Δb with VAS score respectively.n Results:A total of 25 cases (30 lesions) were reviewed, including 13 lesions on the head and neck, 9 in the trunk and 8 in the limbs. VAS evaluation showed that the overall response of fair was in 2 (6.7%) lesion, good in 8 (26.7%) lesion and excellent in 20 (66.7%) lesion. Percentage of excellent response in head and neck, trunk and limbs was 69.2%(9/13), 66.7%(6/9) and 62.5%(5/8) respectively, with no significant difference (n χ2=0.101, n P=0.951). After treatment, L value increased by 9.25±8.96, a value decreased by 4.68±11.08, and b value decreased by 2.44±7.18 respectively, having statistical difference (n t=-8.383, n P<0.001;n t=3.763, n P<0.001;n t=2.813, n P=0.006). ΔL value was positively correlated with VAS score ( n r=0.616, n P<0.001), while Δa value was negatively correlated with VAS score (n r=-0.640, n P<0.001), and Δb value had no correlation with VAS score (n r=-0.028, n P=0.883).n Conclusions:0.5% timolol maleate aqueous solution is effective in the treatment of superficial IH. ΔL and Δa are highly correlated with VAS score, indicating that L n *an *bn * color system accurately reflects the chromatism of the lesion and could be provided as an objective index to evaluate the efficacy of superficial IH.n