Species diversity and ethno-medicinal usage of 39 species of invasive plants were explored in and around two protected areas,Khadinmagar National Park (KNP) and Rema-Kalenga Wildlife Sanctuary (RKWS),of northeastern Bangladesh,.Status of invasive plants were investigated in 60 sample plots with 5 different habitat types,including forest,roadside,homestead,fallow land and others (ponds,canals,water logged areas,agricultural land,etc.).Data about the usage of invasive plants in traditional health care were collected through interviewing 110 households.Among the five habitat types,fallow land (28 species) possessed the highest number of species,followed by roadside (25 species),forest (23 species),homestead (22 species) and others (13 species).Based on the survey,invasive plants of study areas were also categorized into five degrees of invasiveness e.g.,naturalized,introduced,possibly invasive,moderately invasive and highly invasive.Additionally,there is the linear trend between degrees of invasiveness and use percentage of invasive plants.Total 39 species of invasive plants belonging to 29 families were recorded,which are generally used to treat 37 diseases,ranging from simple headache to highly complicated eye and heart diseases.The majority of the species used by the local inhabitants were herbs (16 species),followed by some shrubs (11 species),climbers (5 species),trees (5 species) and grasses (2 species).The use percentage of aboveground plant parts were higher (70.58％) than that of underground plant parts (16.18％).