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目的 :研究我国宫颈癌高发区新疆和田地区维族妇女宫颈癌发病与人类乳头瘤病毒(HPV)的关系。方法 :对50例新疆和田地区维族宫颈癌患者癌组织标本采用PCR(聚合酶联反应)技术 ,检测HPV C(总的HPV) ,HPV16 ,HPV18及HPV6/11。结果 :HPV C ,HPV16,HPV18及HPV6/11在宫颈癌病人中的检出率分别为80.0% ,66.0% ,10.0% ,0 % ,HPV16在HPV阳性患者中占的比例为91.4 % ,鳞癌HPV16阳性率明显高于腺癌 ,而腺癌HPV18检出率明显高于鳞癌(P<0.05) ,HPV总感染率及HPV16阳性率与宫颈癌临床分期及病理分级之间无显著差异。结论 :HPV感染与我国宫颈癌高发区新疆维族妇女宫颈癌发病有密切关系 ,其中 ,HPV16感染在新疆和田地区维族妇女宫颈癌发病中起主要作用 ,HPV感染与宫颈癌临床分期及病理分级无关
Objective: To study the relationship between cervical cancer in Uygur women and human papillomavirus (HPV) in Xinjiang Hetian area, a high incidence of cervical cancer. Methods: PCR (Polymerase Chain Reaction) was used to detect HPV C (total HPV), HPV16, HPV18 and HPV6 / 11 in 50 cases of Uygur cervical cancer patients in Hetian area, Xinjiang. Results: The detection rates of HPV C, HPV16, HPV18 and HPV6 / 11 in patients with cervical cancer were 80.0%, 66.0%, 10.0% and 0%, respectively. The proportion of HPV16 in HPV positive patients was 91.4% The positive rate of HPV16 was significantly higher than that of adenocarcinoma, while the positive rate of HPV18 in adenocarcinoma was significantly higher than that in squamous cell carcinoma (P <0.05). There was no significant difference in the total HPV infection rate and HPV16 positive rate between cervical cancer and clinical stage and pathological grade. Conclusions: HPV infection is closely related to the incidence of cervical cancer in Uygur women in Xinjiang. Among them, HPV16 infection plays a major role in the development of Uygur women with cervical cancer in Hetian, Xinjiang. HPV infection is not associated with the clinical stage and pathological grade of cervical cancer