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现代有毒中药的概念是使用不当时,损伤人体的组织、器官,扰乱或破坏正常生理功能,产生病理变化甚至可能危及生命的中药。《中国药典》2010年版共收载毒性中药83种,其中大毒10种,有毒42种,小毒31种。目前我国在有毒中药的药效组分学研究、毒代动力学研究、代谢组学研究等方面都取得了一定进展,但也存在纳入中药安全性评价研究的种类少、研究方法较局限、管理尚不规范等问题。借鉴国外安全性评价方法、制定严格规范的质量标准等都是保障有毒中药合理应用的有效方法。
The concept of modern toxic traditional Chinese medicine is improper use, damage the body’s tissues and organs, disrupt or destroy the normal physiological function, pathological changes may produce life-threatening Chinese medicine. The Chinese Pharmacopoeia 2010 edition contains 83 kinds of traditional Chinese medicines, of which 10 are toxic, 42 are toxic and 31 are small. At present, some progress has been made in pharmacodynamics, toxicokinetics and metabolomics in toxicant Chinese medicine. However, there are still a few types of studies on the safety evaluation of traditional Chinese medicines, and the research methods are limited. Management Not yet standardized and other issues. Learning from foreign safety evaluation methods and formulating strict and standard quality standards are all effective methods to ensure the rational application of toxic traditional Chinese medicine.