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目的 :观察TPA的强心作用及抗心律失常作用。方法 :Langendorff灌流离体豚鼠心脏 ,观察药物对心脏收缩力及心率的影响 ;用氯仿致小鼠心律失常 ,观察TPA对心脏的保护作用。结果 :1 0 3mol·L 1TPA二甲亚砜液、1 0 3mol·L 1盐酸TPA液都能非常显著地加强心脏收缩力 ,增幅分别达 1 86± 40 % (P <0 .0 1 ,n =8)、1 64± 3 1 % (P <0 .0 1 ,n =9) ,其强心作用与阳性对照 (7.0 6× 1 0 6 mol·L 1毒毛旋花甙K ,增幅 1 94± 42 % ,n =6)相比无显著性差异彩 ;TPA对心率及心跳节律影响较小。TPA有抗氯仿致小鼠室颤的作用 ,3 0mg·kg 1TPA组室颤发生率 (3 8% ,n =2 1 )与阴性对照发生率 (88% ,n =1 6)相比有非常显著的差异 (P <0 .0 1 )。结论 :TPA有较强增强心肌收缩力作用及抗心律失常作用 ,有进一步研究的价值
Objective: To observe the cardiac function and antiarrhythmic effect of TPA. Methods: Langendorff perfusion guinea pig heart perfusion, observe the effect of drugs on cardiac contractility and heart rate; chloroform induced arrhythmia in mice, observe the protective effect of TPA on the heart. Results: The contractility of cardiac muscle was enhanced remarkably by 1 0 3 mol·L 1 TPA dimethyl sulfoxide solution and 1 0 3 mol·L 1 hydrochloric acid TPA solution, respectively, with an increase of 1 86 ± 40% (P <0 01, n = 8), 1 64 ± 3 1% (P <0.01, n = 9), and its cardiac function was positively correlated with the positive control (7.0 6 × 106 mol·L -1 velvet K, 94 ± 42%, n = 6); TPA had little effect on heart rate and heart rhythm. TPA had the effect of anti-chloroform-induced murine ventricular fibrillation. The incidence of VF in 30 mg · kg -1 TPA group (38%, n = 21) was significantly lower than that of the negative control (88%, n = 16) Significant difference (P <0.01). Conclusion: TPA has a stronger effect of enhancing myocardial contractility and anti-arrhythmic effect, and has further research value