三磷酸腺苷(以下简称ATP)及辅酶A的临床应用日渐广泛,究竟其生理、药理作用如何?有无副作用?长期反复使用有无必要,是否合适?特就这些问题查阅有关文献,综述如下: (一)ATP、辅酶A的生理作用 ATP是高能磷酸化合物之一,在身体各种组织中都有。一个分子ATP含有两个高能磷酸键,其中一个键水解时放出能量,供人体生理活动所利用。肌肉内有不同的酶系可以氧化糖、脂肪、蛋白而产生ATP。而肌肉内又有磷酸化酶,使ATP分解释放出能量,供物质氧化及肌肉收缩所利用。故其生理作用既涉及到糖、蛋白质及脂肪的代谢,又涉及到骨胳肌、平滑肌的收缩活动,甚至亦间接与内分 Adenosine triphosphate (hereinafter referred to as ATP) and coenzyme A clinical application of a wide range of, after all, how its physiological and pharmacological effects? With or without side effects? Long-term repeated use of the need for, is appropriate? Special to these issues consult the literature, reviewed as follows: ) ATP, the physiological role of coenzyme A ATP is one of the high-energy phosphate compounds, in all tissues of the body. One molecule, ATP, contains two high-energy phosphate bonds, one of which releases energy when hydrolyzed for use by human physiology. There are different enzymes in the muscle can oxidize sugar, fat, protein and produce ATP. The muscle has phosphorylase, the ATP decomposition of the release of energy for the material used in the oxidation and muscle contraction. Therefore, its physiological role involves not only the metabolism of sugar, protein and fat, but also related to the contraction of skeletal muscle and smooth muscle activity, even indirectly and internally