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目的 探讨大肠癌组织的微血管计数 (MVC)对肝转移的诊断作用。方法 用抗Ⅷ因子相关抗原的单克隆抗体进行微血管内皮细胞免疫组化染色 ,分别计数有肝转移 5 8例大肠癌和无肝转移 74例大肠癌的微血管数量 ,并进行统计学比较。结果 肝转移组大肠癌组织的平均MVC为 2 8 66±5 2 4 ,其中大于 2 0支的病例占 89 65 % ,而无肝转移组的大肠癌组织分别只有 19 98± 4 96和12 16% ,两组MVC有极显著差异。结论 大肠癌组织的MVC高者发生肝转移可能性较大 ,多于 2 0支时这种可能性达到 85 2 5 % ,MVC对肝转移的诊断作用和检测癌胚抗原作用相似 ,但各有优缺点 ,可以互补。
Objective To investigate the diagnostic value of microvascular count (MVC) in colorectal carcinoma on liver metastasis. Methods The microvessel endothelial cells were immunohistochemically stained with monoclonal antibody against factor Ⅷ related antigen, and the number of microvessels in 58 cases with liver metastases and 74 cases with non-liver metastases were counted and compared statistically. Results The mean MVC of colorectal cancer in liver metastasis group was 2866 ± 524, of which 89 65% were in more than 20 cases, while those in non-liver metastasis group were only 19 98 ± 4 96 and 12 16 %, Two groups of MVC have very significant differences. Conclusions The patients with MVC in colorectal cancer are more likely to develop liver metastasis. When the number is higher than 20, the probability of liver metastasis is 85.25%. The diagnostic value of MVC for liver metastasis is similar to that of detecting carcinoembryonic antigen, but each has Pros and cons, can complement each other.