目的探讨改良超长方案对卵巢低反应患者体外受精-胚胎移植结局的影响。方法 200例行体外受精-胚胎移植治疗的促排卵卵巢低反应患者,随机分为观察组和对照组,每组100例。观察组采用改良超长方案治疗,对照组采用拮抗剂方案治疗,比较两组用药情况、治疗情况、受精情况及临床妊娠率。结果两组患者促性腺激素(Gn)总量、Gn使用时间、人绒毛膜促性腺激素(HCG)日促黄体生成素(LH)水平比较差异有统计学意义(P<0.05);两组HCG日内膜厚度比较,差异无统计学意义(P>0.05)。观察组患者平均取卵数(7.8±4.6)个、受精率为75.0%、移植胚胎数(1.99±0.54)个、优质胚胎率59.0%、临床妊娠率50.0%、流产率8.0%、活产率40.0%,对照组患者平均取卵数(6.0±3.4)个、受精率为55.0%、移植胚胎数(1.92±0.58)个、优质胚胎率55.0%、临床妊娠率30.0%、流产率9.0%、活产率20.0%,观察组患者受精率、妊娠率、活产率明显高于对照组(P<0.05)。结论改良超长方案可提高卵巢低反应患者的受精率和临床妊娠率,其效果优于拮抗剂方案,值得临床应用。 Objective To investigate the effect of modified overlength regimen on outcome of in vitro fertilization and embryo transfer in patients with low ovarian response. Methods A total of 200 ovarian - ovarian - ovarian response patients undergoing in vitro fertilization - embryo transfer were randomly divided into observation group and control group with 100 cases in each group. The observation group was treated with improved long-term regimen. The control group was treated with the antagonist regimen. The medication, treatment, fertilization and clinical pregnancy rate were compared between the two groups. Results The total amount of gonadotropin (Gn), Gn use time and human luteinizing hormone (HCG) day luteinizing hormone (LH) levels in the two groups were significantly different (P <0.05). The HCG Intraday thickness of the film, the difference was not statistically significant (P> 0.05). The average number of oocytes fetched in the observation group was 7.8 ± 4.6, the fertilization rate was 75.0%, the number of embryos transferred (1.99 ± 0.54), the rate of high quality embryos was 59.0%, the clinical pregnancy rate was 50.0%, the miscarriage rate was 8.0% and the live birth rate The mean number of embryos in control group was 6.0 ± 3.4, the fertilization rate was 55.0%, the number of embryos transferred was 1.92 ± 0.58, the rate of high quality embryos was 55.0%, the clinical pregnancy rate was 30.0%, the miscarriage rate was 9.0% The live birth rate was 20.0%. The fertilization rate, pregnancy rate and live birth rate in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Improved long program can improve the fertilization rate and clinical pregnancy rate of patients with low ovarian response, the effect is better than the antagonist program, worthy of clinical application.