【摘 要】
：
金属蛋白酶(MMPs)对细胞外基质(胶原、明胶、纤维连接素)的过度水解,是恶性肿瘤播散及转移的重要原因,金属蛋白酶抑制剂(TIMPs)能否抑制其对基质的破坏、改善细胞外微环境并
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金属蛋白酶(MMPs)对细胞外基质(胶原、明胶、纤维连接素)的过度水解,是恶性肿瘤播散及转移的重要原因,金属蛋白酶抑制剂(TIMPs)能否抑制其对基质的破坏、改善细胞外微环境并起到限瘤作用,已引起有关学者的关注。作者通过建立裸鼠胰腺癌肝转移模型,观察BB-94(一种广谱的TIMPs)对
Excessive hydrolysis of extracellular matrix (collagen, gelatin, fibronectin) by metalloproteinases (MMPs) is the important reason for the dissemination and metastasis of malignant tumors. Whether TIMPs can inhibit the destruction of matrix and improve Extracellular microenvironment and play a limited tumor effect, has drawn the attention of scholars. By establishing a model of liver metastasis of pancreatic cancer in nude mice, the authors observed the effect of BB-94 (a broad spectrum of TIMPs)
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