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目的研究FLEEOX新辅助化疗方案对进展期胃癌患者营养状况的影响。方法根据纳入和排除标准,共选择2010年12月至2011年10月期间我科收治的难以手术切除并进行了新辅助化疗的48例胃癌患者,利用机体组成分析仪测定化疗前、后机体组成成分的变化,同时检测血液相关营养学指标。结果患者化疗后,体重、细胞内液、体重指数、蛋白质、体脂肪、体细胞群及上臂周长均较化疗前表现为略下降,而细胞外液、身体水分含量、无机盐、骨骼矿物质含量、非脂群、骨骼肌及上臂无脂肪周长较化疗前均表现为略轻度上升,但各项指标差异均无统计学意义(P>0.05);血液中白蛋白、前白蛋白、总蛋白、转铁蛋白及淋巴细胞均较化疗前出现不同程度下降,但差异均无统计学意义(P>0.05)。结论进展期胃癌患者接受化疗期间营养状况无明显变化,FLEEOX新辅助化疗未加重患者营养不良的状况。
Objective To investigate the effect of FLEEOX neoadjuvant chemotherapy on nutritional status in patients with advanced gastric cancer. Methods According to the inclusion and exclusion criteria, a total of 48 patients with gastric cancer who were difficult to be surgically treated with neoadjuvant chemotherapy and were treated in our department between December 2010 and October 2011 were selected. Body composition analyzer was used to determine the body composition before and after chemotherapy Changes in composition, while testing blood-related nutritional indicators. Results After chemotherapy, the body weight, intracellular fluid, body mass index, protein, body fat, somatic cell mass and upper arm circumference slightly decreased compared with those before chemotherapy. However, extracellular fluid, body water content, inorganic salts and bone mineral content, The non-fat group, skeletal muscle and upper arm fat-free circumference compared with before chemotherapy showed a slight increase, but there was no significant difference between the various indicators (P> 0.05); blood albumin, prealbumin, total protein , Transferrin and lymphocytes decreased compared with before chemotherapy, but the difference was not statistically significant (P> 0.05). Conclusion The nutritional status of patients with advanced gastric cancer during chemotherapy did not change significantly, FLEEOX neoadjuvant chemotherapy did not aggravate the malnutrition of patients.