一、概述 (一)发病率 1960年Delay和Deniker首先报告抗精神病药(APD)引起的恶性综合征(NMS)。Pope等(1986)估计其发病率为1.4±0.5％。国内从70年代迄今,共报道17例。邓氏在1980～1986年间,用APD治疗10080例病人,13例发生NMS,发病率1.28‰,与Pope估计的要低,这可能与国外用药剂量大有关。 (二)易感人群 NMS可发生于任何年龄,40岁以下的约75％。多见于脑器质性损害者、药量蓄积者及高效价APD肌注者。精神病人与非精神病人均可发病,男女之比为2:1。 (三)死亡率近年报道,NMS死亡率在下 I. Overview (A) Incidence 1960 Delay and Deniker first report antipsychotics (APD) -related malignant syndrome (NMS). Pope et al. (1986) estimated the incidence to be 1.4 ± 0.5%. Domestic since the 70s so far, a total of 17 cases were reported. Deng from 1980 to 1986, APD treatment of 10,080 patients, 13 cases of NMS, the incidence of 1.28 ‰, and Pope estimated lower, which may be related to large doses of foreign drugs. (B) Susceptible populations NMS can occur at any age, about 75% under the age of 40. More common in brain organic damage, drug accumulation and high titer APD intramuscular injection. Mental illness and non-mental illness can be disease, male to female ratio of 2: 1. (C) the mortality rate reported in recent years, NMS mortality rate in the next