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60岁黑人妇女,因长期患有突限性甲状腺肿,出现甲状腺功能亢进,曾使用他巴唑治疗,并伴有周身水肿与充血性心力衰竭,日排出尿蛋白32克的肾病综合征,光镜与电镜检查,显示出膜性肾小球性肾炎第Ⅱ期,直接与间接免疫证明IgM与IgG,在标本中补体,甲球蛋白微粒与肾小球肾炎的免疫复合物是相同的,在甲状腺全切后11个月的追踪观察,其肾小球过滤无多大改变,可是却导致了蛋白尿的减少,我们认为这是在突眼性甲状腺肿中肾小球肾炎免疫复合物与甲状腺抗原结合的首次报告.
60-year-old black woman, due to long-term suffering from goiter, thyroid hyperthyroidism, had been treated with methimazole, accompanied by peripheral edema and congestive heart failure, urinary protein excretion 32 grams of nephrotic syndrome, light Microscopy and electron microscopy showed that membranous glomerulonephritis stage II, direct and indirect immunological evidence of IgM and IgG, in the specimens of complement, microglobulin particles and glomerulonephritis immune complexes are the same, in the Follow-up observation of 11 months after total thyroidectomy showed no significant change in glomerular filtration, but resulted in a decrease of proteinuria. We think this is a combination of glomerulonephritis immune complex and thyroid antigen Combined first report.