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目的通过癌性恶病质动物模型探讨血清中胰岛素样生长因子-I(IGF-I)水平在癌性恶病质中的作用。方法将小鼠结肠腺癌26细胞悬液接种于肝脏特异性IGF-I基因缺失(LID)组鼠和对照组鼠皮下,各30只接受了肿瘤细胞接种。接种后监测两组小鼠的一般情况、体重和皮下肿瘤大小以及自然生存时间。结果LID鼠和对照鼠进入恶病质的时间分别为(14.6±1.3)d、(24.1±2.5)d;生存时间分别为(19.3±1.3)d、(31.9±2.7)d,两者差异有极显著性意义(P<0.01)。结论血清中低水平的IGF-I虽然可以延缓肿瘤的生长,但是却促进了癌性恶病质的发生和发展。
Objective To investigate the role of serum insulin-like growth factor-I (IGF-I) levels in cancerous cachexia through an animal model of cancerous cachexia. Methods Mouse colon adenocarcinoma 26 cell suspension was inoculated into liver-specific IGF-I gene-deficient (LID) mice and control mice, and 30 mice in each group received tumor cell inoculation. After inoculation, the general condition, weight and subcutaneous tumor size, as well as the natural survival time of the two groups of mice were monitored. Results The time of entering cachexia was (14.6 ± 1.3) days and (24.1 ± 2.5) days respectively in LID rats and control rats. The survival time was (19.3 ± 1.3) days and (31.9 ± 2.7) days, respectively Sexual significance (P <0.01). Conclusions Low serum IGF-I levels in serum may delay the tumor growth, but promote the development and progression of cancerous cachexia.