结节病是一种少见的病因未明的多系统肉芽肿性疾病,最常侵犯的部位是双侧肺门、纵隔和周围淋巴结,肺、肝、脾、皮肤、眼、腮腺、指骨等次之。结节病的主要病理学改变是上皮样细胞构成的肉芽肿性结节,无干酪样坏死,病变中常见多核巨细胞。巨细胞内偶见星状体或排列呈同心层状舒曼(Schaumann)氏小体等包涵物。Kveim试验(结节病抗原皮肤试验)常呈阳性。结核菌素试验常呈阴性。可有高钙血症、尿钙症和血清球蛋白增高。 Sarcoidosis is a rare, multisystem granulomatous disease of unknown etiology. The most frequent sites of invasion are bilateral hilar, mediastinal and peripheral lymph nodes, lung, liver, spleen, skin, eyes, parotid glands, and phalanges . The main pathological changes of sarcoidosis are granulomatous nodules composed of epithelioid cells, with no caseous necrosis and common multinucleated giant cells in the lesions. Occasional occasional astrocytes in the giant cells or arranged in concentric layered Schaumann’s body inclusions. The Kveim test (sarcoid antigen skin test) is often positive. Tuberculin test often negative. May have hypercalcemia, urinary calcium disease and serum globulin increased.