原发性骨髓发育不良综合征(MDS)的特征是骨髓成熟过程中发生前白血病克隆缺陷,造成血细胞减少.中位生存时间8～27个月.维生素D的活性代谢物1,25-二羟基维生素D_3(1,25〔OH〕_2D_3)能诱导白血病细胞分化,然而临床治疗MDS病人,效果令人失望,在引起高钙血症方面仍缺乏疗效.作者联用维生素D(大剂量口服)、降钙药治疗6例MDS,3例获得了扶久血液学疗效.治疗方 Primary myelodysplastic syndrome (MDS) is characterized by premalignant leukemia clonality during bone marrow maturation, resulting in cytopenias with a median survival of 8-27 months, and the active metabolite of vitamin D, 1,25-dihydroxy Vitamin D_3 (1,25 〔OH〕 _2D_3) can induce leukemia cell differentiation, however, clinical treatment of MDS patients, the effect is disappointing, in the cause of hypercalcemia is still lack of efficacy.Using vitamin D (high-dose oral) 6 cases of MDS were treated with calcium-lowering drugs, and 3 cases of Fujiu hematological efficacy were obtained