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目的采用超声造影技术对宫颈癌进行定量和定性分析,并探讨超声造影特点与p16、p53表达的关系。方法回顾性分析经手术已证实的40例宫颈癌患者,术前均行超声造影检查,记录超声造影增强特点和时间-强度曲线参数的特征,术后采用免疫组化法测定p16、p53表达的情况,并分析宫颈癌超声造影特征与p16、p53表达的关系。结果 (1)宫颈癌患者p16、p53阳性表达率分别为80%(32/40)和67.5%(27/40);(2)与p16、p53表达阴性组比较,p16、p53表达阳性组不均匀性增强和灌注缺损的概率均明显增加,两组之间的差异有统计学意义(P=0.025,P=0.020;P=0.015,P=0.006);(3)与p16、p53表达阴性组比较,p16、p53表达阳性组峰值强度(PI)均显著增高,差别具有统计学意义(t=2.307,P=0.027;t=3.012,P=0.005)。结论宫颈癌超声造影特征与p16、p53阳性表达之间存在一定关系,通过两者的综合评价,能够为宫颈癌的评估提供更有价值的临床信息。
Objective To evaluate the quantitative and qualitative analysis of cervical cancer by contrast-enhanced ultrasound and to explore the relationship between the characteristics of ultrasound and the expression of p16 and p53. Methods Forty cases of cervical cancer confirmed by surgery were retrospectively analyzed. The echocardiography was performed preoperatively to record the characteristics of enhanced contrast-enhanced ultrasound and time-intensity curve parameters. The expression of p16 and p53 was detected by immunohistochemistry And analyze the relationship between CEUS features and the expression of p16 and p53 in cervical cancer. Results (1) The positive rates of p16 and p53 in cervical cancer patients were 80% (32/40) and 67.5% (27/40), respectively. (2) Compared with p16 and p53 negative cells, p16 and p53 positive cells were not (P = 0.025, P = 0.020; P = 0.015, P = 0.006). (3) Compared with the patients with negative expression of p16 and p53, the difference between the two groups was statistically significant (P = 0.027; t = 3.012, P = 0.005). The difference was statistically significant (P <0.05). Conclusion There is a certain relationship between CEUS features and the positive expression of p16 and p53. Through the comprehensive evaluation of both, it can provide more valuable clinical information for the evaluation of cervical cancer.