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采用 IL ISA法测定了哮喘发作期和缓解期患儿的血清白介素 - 12 ( IL- 12 )和白介素 - 4 ( IL- 4 )。结果发现 ,发作期哮喘患儿 IL - 12水平 ( 3 5 .2± 11.18pg/ ml)显著低于缓解期 ( 4 2 .75± 13 .3 8pg/ ml)和健康儿 ( 4 5 .4 3±2 9.19pg/ ml) ,P分别 <0 .0 1、0 .0 5。发作期和缓解期哮喘患儿血清 IL - 4阳性率 (分别为 5 5 .5 6%和 3 6.3 6% )均显著高于健康儿 ( 9.1% ) ,P分别 <0 .0 1、0 .0 5。IL- 12和 IL- 4呈显著负相关 ( r=- 0 .3 4 ,P<0 .0 5 )。认为哮喘患儿存在明显的 Th1 / Th2 类细胞因子失衡 ,IL- 12和 IL- 4在哮喘发病中都起重要作用。吸入糖皮质激素等治疗可改变这种失衡状态。
Serum levels of IL-12 and IL-4 in children with asthma and remission were measured by IL-ISA. The results showed that IL - 12 levels in children with asthma at the onset stage were significantly lower than those in the remission stage (4.275 ± 13.38pg / ml) and healthy children (45.33% ± 2 9.19 pg / ml), P <0.0 1, 0 .0 5, respectively. The positive rates of IL - 4 in children with asthma during the attack and remission stages were significantly higher than those in healthy children (55.56% and 3 6.36%, respectively) (P <0.05). 0 5. There was a significant negative correlation between IL-12 and IL-4 (r = -0.34, P <0.05). It is thought that there is a clear imbalance of Th1 / Th2 cytokines in children with asthma, and both IL-12 and IL-4 play an important role in the pathogenesis of asthma. Inhalation of glucocorticoids and other treatments can change this imbalance.