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自从 1 969年Ｃｏｔｚｉａｓ确认了口服左旋多巴治疗帕金森病 (Ｐａｒｋｉｎｓｏｎｄｉｓｅａｓｅ ,ＰＤ)的疗效以来 ,左旋多巴一直是治疗ＰＤ的“金标准”。但用左旋多巴治疗 5年后 ,有 50 %以上的患者会出现药效消失、运动波动等“长期左旋多巴综合征”。左旋多巴控释剂 (或
Levodopa has been the “golden standard” for treating PD since Cotzias confirmed the efficacy of oral levodopa in the treatment of Parkinson’s disease (PD) in 1969. However, with levodopa 5 years after treatment, more than 50% of patients will appear disappeared, movement fluctuations and other “long-term levodopa syndrome.” Levodopa Controlled Release (or