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目的探讨环孢菌素A(CsA)联合免疫球蛋白(IVIG)治疗难治性特发性血小板减少性紫癜(ITP)的疗效。方法选择31例难治性ITP患者,采用CsA联合IVIG治疗,剂量分别为5mg/(kg.d)和0.4g/(kg.w)。结果与治疗前相比,治疗后血小板计数明显升高(P<0.01),总有效率为71.8%。结论 CsA联合IVIG可作为难治性ITP的一种有效治疗方法。
Objective To investigate the efficacy of cyclosporine A (CsA) combined with immunoglobulin (IVIG) in the treatment of refractory idiopathic thrombocytopenic purpura (ITP). Methods Thirty-one patients with refractory ITP were selected and treated with CsA combined with IVIG at doses of 5 mg / (kg · d) and 0.4 g / (kg · w), respectively. Results Compared with those before treatment, the platelet count was significantly increased after treatment (P <0.01), with a total effective rate of 71.8%. Conclusion CsA combined with IVIG can be used as an effective treatment for refractory ITP.