论文部分内容阅读
目的:探讨安络化纤丸辅助治疗原发性胆汁性肝硬化的疗效及其对患者免疫学指标的影响。方法:选取84例原发性胆汁性肝硬化患者为研究对象,随机分为观察组和对照组,每组42例。对照组:给予甘草酸二铵葡萄糖注射液联合熊去氧胆酸片治疗。观察组:给予安络化纤丸辅助甘草酸二铵葡萄糖注射液联合熊去氧胆酸片治疗。观察比较两组患者疗效、不力引发、临床症状、症状积分、肝功能、肝纤维化指标、门脉血流动力学、Ig G及Ig M水平的变化情况。结果:治疗5、16及24周,观察组黄疸、乏力、皮肤瘙痒及肝区不适等临床症状改善情况均优于对照组,差异均有统计学意义(P<0.01~0.05)。治疗5、16及24周,观察组症状积分、肝功能ALT、AST、TBIL、肝纤维化相应指标等都低于对照组,差异均有统计学意义(P<0.01~0.05)。治疗后,观察组门脉血流动力学SV及PV水平变化都优于对照组,差异均有统计学意义(P<0.05)。治疗24周后,观察组Ig G及Ig M水平都低于对照组,差异均有统计学意义(P<0.01~0.05)。治疗24周后,观察组显效率71.4%高于对照组显效率45.2%,差异有统计学意义(P<0.05)。结论:安络化纤丸辅助治疗原发性胆汁性肝硬化疗效显著,能够有效缓解患者黄疸、乏力等临床症状及体征,降低症状积分及肝纤维化指标水平,并可以改善患者的免疫学指标。
Objective: To investigate the curative effect of Anluo Huaxian Pills in adjuvant treatment of primary biliary cirrhosis and its influence on immunological indexes of patients. Methods: Eighty-four patients with primary biliary cirrhosis were randomly divided into observation group and control group, with 42 cases in each group. Control group: given diammonium glycyrrhizinate glucose injection combined with ursodeoxycholic acid tablets. Observation group: given Anluohuaxiang pill assisted diammonium glycyrrhizinate glucose injection combined with ursodeoxycholic acid tablets treatment. The curative effect, insomnia, clinical symptoms, symptom score, liver function, hepatic fibrosis index, portal hemodynamics, Ig G and Ig M levels in two groups were observed and compared. Results: At 5, 16 and 24 weeks after treatment, the clinical symptoms such as jaundice, fatigue, pruritus and liver discomfort in the observation group were better than those in the control group. The differences were statistically significant (P <0.01 ~ 0.05). At 5, 16 and 24 weeks of treatment, symptom scores, liver function ALT, AST, TBIL and corresponding indexes of liver fibrosis in the observation group were lower than those in the control group, with statistical significance (P <0.01-0.05). After treatment, the portal vein hemodynamics SV and PV levels in the observation group were better than those in the control group, with statistical significance (P <0.05). After 24 weeks of treatment, the levels of Ig G and Ig M in the observation group were lower than those in the control group, with significant differences (P <0.01 ~ 0.05). After 24 weeks of treatment, the markedly effective rate of observation group was 71.4%, which was significantly higher than that of control group (45.2%), the difference was statistically significant (P <0.05). Conclusion: Anluo Huaxian Pill can significantly reduce the clinical symptoms and signs of jaundice and fatigue, reduce symptom scores and liver fibrosis indexes, and can improve the immunological indexes of patients with primary biliary cirrhosis.