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目的 观察氟康唑预防、治疗急性白血病合并霉菌感染的疗效及其毒副作用。方法 将 112例次急性白血病患者分为两组。A组共 2 5例次 ,在化疗后外周血白细胞低于 2 .0× 10 9/L时即予常规口服氟康唑 10 0mg/d共 7d ;B组共 87例次 ,仅在白血病患者化疗后符合霉菌感染诊断标准[2 ] 情况下予静脉用氟康唑 2 0 0mg/d治疗。观察急性白血病合并霉菌感染的特点 ;并对照两组患者霉菌感染的发生率及氟康唑的毒副作用。结果 A、B两组患者中霉菌感染发生率有明显差异 (χ2 =4.2 1,P <0 .0 5 ) ;急性白血病患者易合并消化道、呼吸道及泌尿系统霉菌感染 ;氟康唑未见有严重毒副作用。结论 口服氟康唑能安全、有效地预防急性白血病合并霉菌感染
Objective To observe the efficacy and side effects of fluconazole in the prevention and treatment of acute leukemia complicated with fungal infection. Methods 112 patients with subacute leukemia were divided into two groups. A total of 25 patients in the A group were treated with conventional oral fluconazole 100 mg/d for 7 days after chemotherapy when the peripheral blood leukocytes were below 2.0 × 10 9/L; 87 patients in the B group were treated only with leukemia After chemotherapy, it was treated with intravenous fluconazole 200 mg/d in accordance with the diagnostic criteria for fungal infection [2]. Observe the characteristics of acute leukemia with mycotic infection; control the incidence of mycotic infection and toxic side effects of fluconazole in both groups. Results There was a significant difference in the incidence of mycotic infection in patients A and B (χ2 =4.21, P<0.05). Patients with acute leukemia were easily associated with fungal infections of the digestive tract, respiratory tract, and urinary system; Fluconazole was not found Serious toxic side effects. Conclusion Oral fluconazole can safely and effectively prevent acute leukemia and fungal infection