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目的 探讨乳腺癌根治术与扩大根治术治疗II ,III期乳腺癌的疗效。方法 回顾性分析691例II ,III期乳腺癌的两种手术方法治疗后的 5年和 10年生存率。 691例乳腺癌中II期行根治术 2 0 6例 ,行扩大根治术 14 2例 ;III期行根治术 193例 ,行扩大根治术 15 0例。结果 癌灶位于中央区及内乳区行扩大根治术的II ,III期患者的 5年生存率和III期的 10年生存率显著高于根治术患者 (均P <0 .0 1)。癌灶位于外上象限行扩大根治术的II ,III期患者 10年生存率和III期患者的 5年生存率亦显著高于根治术患者 (均 P <0 .0 5 )。结论 提示II ,III期乳腺癌病灶位于中央区及内乳区的患者、位于外上象限的III期患者应考虑行扩大根治术。
Objective To investigate the curative effect of radical mastectomy and extended radical mastectomy on stage II and III breast cancer. Methods The 5-year and 10-year survival rates of 691 cases of stage II and III breast cancer were retrospectively analyzed. In 691 cases of breast cancer, 206 patients underwent radical resection in stage II, with 142 patients undergoing radical resection; 193 patients undergoing radical resection in stage III and 150 patients undergoing radical resection. Results The 5-year survival rates and 10-year survival rates of patients with stage II and III disease who underwent radical mastectomy in central and internal breast cancer were significantly higher than those in radical operation (all P <0.01). The 10-year survival rates of patients with stage II and III tumors with extended upper-extremity and the 5-year survival rate of patients with stage III disease were also significantly higher than those with radical surgery (all P <0.05). Conclusions The patients with stage II and III breast cancer lesions in the central region and the internal mammary region suggest that extended radical mastectomy should be considered in stage III patients located in the upper quadrant.