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目的探讨有机磷农药中毒抢救中阿托品中毒形成的原因,以减少阿托品中毒的发生率。方法对十年间247例有机磷农药中毒抢救中26例阿托品中毒进行回顾性分析。结果247例有机磷农药中毒抢救中发生阿托品中毒26例,阿托品中毒发生率为10.5%。主要症状有谵语、狂躁,HR≥110次/min,T>38.5℃,瞳孔≥5mm。发生尿潴留8例,昏迷4例;血红蛋白尿3例,抽搐1例,溶血性黄疸1例。4例以40mg每10min的速度静脉注射阿托品,入院5h内阿托品使用剂量占阿托品使用总量的84.1%～91%,均发生阿托品中毒。结论盲目使用阿托品,片面强调阿托化的某一项指标是有机磷中毒抢救过程中阿托品中毒的主要原因。
Objective To investigate the causes of atropine poisoning in the rescue of organophosphorus pesticide poisoning to reduce the incidence of atropine poisoning. Methods A retrospective analysis of 26 cases of atropine poisoning in 247 cases of organophosphorus pesticide poisoning during a decade was conducted. Results 247 cases of organophosphorus pesticide poisoning occurred in atropine poisoning in 26 cases, atropine poisoning rate of 10.5%. The main symptoms are slurred speech, manic, HR ≥ 110 times / min, T> 38.5 ℃, pupils ≥ 5mm. Occurred in 8 cases of urinary retention, coma in 4 cases; 3 cases of hemoglobinuria, convulsions in 1 case, hemolytic jaundice in 1 case. 4 cases of intravenous injection of atropine at a rate of 40mg per 10min, atropine use within 5h admission accounted for 84.1% to 91% of the total amount of atropine use, have occurred atropine poisoning. Conclusions blind use of atropine, one-sided emphasis on one of the indicators of atuo is the main cause of atropine poisoning during the treatment of organophosphate poisoning.