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目的探讨兰州市孕中期母血清筛查及异常妊娠的临床价值。方法以全自动时间分辨仪对10 063例中孕期孕妇血清学标本进行甲胎蛋白(AFP)和游离β人绒毛膜促性腺激素(Freeβ-HCG)检测,并结合孕周、体重、年龄等因素,通过2T风险评估软件进行风险评估。结果在10 063例单胎孕妇中筛查出21-三体高风险327例,占筛查总数3.25%,18-三体高风险45例,占筛查总数0.45%,NTD高风险277例,占筛查总数2.75%。有315例在本院接受产前诊断,经羊水染色体检查,检测出21-三体9例,18-三体3例,其他染色体异常4例。对277例神经管缺陷高风险的孕妇均加强B超检查,确诊69例。结论定期的B超、母血清标志物的筛查以及产前诊断等手段的联合对于预测胎儿染色体疾病有重要的临床价值,可有效降低染色体病患儿的出生。
Objective To investigate the clinical value of maternal serum screening and abnormal pregnancy in the second trimester of Lanzhou. Methods AFP and Free β-HCG were detected in 10 063 pregnant women’s serum samples by automatic time-resolved instrument. Combined with gestational age, body weight, age and other factors , 2T risk assessment software for risk assessment. Results Of 10 063 singleton pregnant women, 327 high-risk 21-trisomy patients were screened, accounting for 3.25% of the total number of screening, 45 high risk of trisomy 18, accounting for 0.45% of the total number of screening, 277 high risk of NTD, Check the total number of 2.75%. There were 315 cases of prenatal diagnosis in our hospital, amniotic fluid chromosomal examination, detected in 21 cases trisomy 9 cases, 3 cases of 18-trisomy, 4 cases of other chromosomal abnormalities. Of 277 cases of high risk of neural tube defects in pregnant women were to strengthen the B-ultrasound, diagnosed in 69 cases. Conclusion The combination of regular B-ultrasound, screening of maternal serum markers and prenatal diagnosis has important clinical value in predicting fetal chromosomal diseases and can effectively reduce the birth of children with chromosomal diseases.