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目的探讨腹泻型肠易激综合征(IBS)与肠黏膜肥大细胞(MC)及脱颗粒之间的关系。方法正常人10例和腹泻型IBS患者11例。每例于结肠镜下取盲肠、横结肠和直肠黏膜组织各2块,用免疫组化方法行MC染色,计算每高倍视野下MC的数量及脱颗粒MC所占MC总数的比例。结果腹泻组IBS患者盲肠、横结肠黏膜MC数量显著高于正常对照组(P<0·01及P<0·05);直肠黏膜MC数量与正常对照组无显著差异(P>0·05)。腹泻型IBS患者盲肠、横结肠、直肠黏膜脱颗粒MC比率显著高于正常对照组(P<0·05或P<0·01)。结论肠黏膜肥大细胞在腹泻型IBS的发病过程中起着重要作用。
Objective To investigate the relationship between diarrhea-predominant irritable bowel syndrome (IBS) and intestinal mucosal mast cells (MC) and degranulation. Methods 10 cases of normal and 11 cases of diarrhea IBS patients. Each case under colonoscopy take cecum, transverse colon and rectal mucosa tissue 2, with immunohistochemistry MC staining, calculate the number of MC per high power field and the proportion of de-granular MC in the total number of MC. Results The numbers of MC in the cecal and transverse mucosa of IBS patients in diarrhea group were significantly higher than those in normal control group (P <0.01 or P <0.05). The number of MC in rectal mucosa was not significantly different from that in control group (P> 0.05). The rate of MC in the cecum, transverse colon and rectal mucosa of diarrhea-predominant IBS patients was significantly higher than that of the normal controls (P <0.05 or P <0.01). Conclusion Intestinal mucosa mast cells play an important role in the pathogenesis of diarrhea-type IBS.