4-苯基丁酮-2是从甘肃省杜鹃属植物烈香杜鹃(Rhododendron anthopogonoides Maxim.)叶的挥发油中分离提取的一种止咳有效成分,现已人工合成,定名为止咳酮。临床验证4-苯基丁酮-2治疗慢性气管炎及急性上呼吸道感染所致咳嗽,疗效较好,且有一定的祛痰、平喘作用。为进一步阐明其治疗作用和为临床安全使用提供实验依据,对其药理作用及毒性进行了探讨,现将结果报道如下。4-苯基丁酮-2由我院化学教研组供应,实验动物由我院动物房供应。 4-phenylbutanone-2 is a cough active ingredient isolated and extracted from the volatile oil of the Rhododendron anthopogonoides Maxim. Leaves of Gansu Province. It has been synthetically synthesized and named as coughone. Clinical validation 4-phenylbutanone -2 treatment of chronic bronchitis and acute upper respiratory tract infection caused by cough, the effect is better, and have a certain expectorant, antiasthmatic effect. In order to further clarify its therapeutic effect and to provide experimental evidence for the clinical use of safety, its pharmacological effects and toxicity were discussed, the results reported below. 4-phenylbutanone -2 by our hospital chemistry teaching and research group supply of laboratory animals provided by our hospital animal room.