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目的:探讨卵巢癌术后腹腔热化疗联合静脉化疗的临床疗效及毒副反应。方法:将卵巢癌术后患者分2组,实验组25例采用顺铂腹腔化疗及热疗+多西他赛全身化疗,对照组23例采用多西他赛全身化疗+顺铂腹腔化疗,比较两组疗效、近期的毒副反应、KPS评分及体重变化。结果:实验组治疗卵巢癌近期有效率、改善率均优于对照组,两组比较差异有统计学意义(P<0.05);两组毒副反应及体重变化比较差异无统计学意义(P>0.05)。实验组KPS评分明显高于对照组,差异有统计学意义(P<0.05)。结论:顺铂腹腔热灌注化疗联合多西他赛全身化疗可显著提高卵巢癌的疗效且不增加毒副作用。
Objective: To investigate the clinical efficacy and toxicity of postoperative intraperitoneal hyperthermic chemotherapy plus intravenous chemotherapy in patients with ovarian cancer. Methods: The postoperative patients with ovarian cancer were divided into two groups. The experimental group (25 cases) received cisplatin intraperitoneal chemotherapy and hyperthermia plus docetaxel systemic chemotherapy. The control group (23 cases) received docetaxel systemic chemotherapy plus cisplatin intraperitoneal chemotherapy. Two groups of curative effect, the recent side effects, KPS score and weight change. Results: The effective rate and the improvement rate of the experimental group in the treatment of ovarian cancer were better than those in the control group, with significant difference between the two groups (P <0.05). There was no significant difference in the toxicity and weight between the two groups (P> 0.05). The KPS score of the experimental group was significantly higher than that of the control group, the difference was statistically significant (P <0.05). Conclusion: Intraperitoneal cisplatin combined with docetaxel chemotherapy can significantly improve the efficacy of ovarian cancer without increasing the toxic and side effects.