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超滤是膜分离技术之一,超滤截留的溶质微粒是分子量在1000～1000000 Dalton之间的高分子,溶液中的蛋白质、多糖、核酸等生物大分子均可被适当的超滤膜截留,水、无机盐及其它小分子溶质则可通过超滤膜滤出。 70年代以来,由于高流速、大容量超滤设备的出现,工业规模血液制品生产中日益广泛地应用超滤浓缩、脱盐或换盐。现就此作一简要介绍。生产规模超滤设备的特征一、采用切向流过滤模式克服浓度极化这是现代工业级超滤器的普遍特征之一。浓度极化是被处理液中溶质微粒在过滤时形成的次生凝胶层,是阻碍膜过滤的最大障碍,切向流过滤是使被处理溶液平行于滤膜表面流动,溶液在压力作用下垂直
Ultrafiltration is one of the membrane separation technology. The ultrafiltration solute particles are macromolecules with a molecular weight between 1,000 and 1,000,000 Dalton. Proteins, polysaccharides, nucleic acids and other biological macromolecules in the solution can be intercepted by an appropriate ultrafiltration membrane, Water, inorganic salts and other small molecule solutes can be filtered through an ultrafiltration membrane. Since the 1970s, due to the advent of high-flow rate and large-capacity ultrafiltration equipment, ultrafiltration concentration, desalination or salt exchange has been increasingly used in the production of industrial-scale blood products. Now make a brief introduction. Characteristics of the production scale ultrafiltration equipment First, the use of tangential flow filtration mode to overcome the concentration polarization This is one of the common features of modern industrial ultrafiltration. Concentration polarization is solute particles in the treatment solution formed during filtration of the secondary gel layer is the biggest obstacle to prevent membrane filtration, tangential flow filtration is to be treated solution parallel to the membrane surface flow, the solution under pressure vertical