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目的评价低剂量铂类化疗同步放射治疗治疗宫颈癌的临床效果和不良反应。方法选取2008年9月至2011年5月治疗的82例宫颈癌患者,化疗采用奈达铂或顺铂20mg/m2,每周一次,同期联合常规分割放射治疗及后装治疗,放射治疗总剂量为8000~8500c Gy。结果近期有效率达100%,1、2、3年生存率分别为90.2%、78.3%和76.3%。晚期放射损伤主要表现为放射性直肠炎及放射性膀胱炎,经积极治疗后均治愈或好转。结论低剂量铂类化疗联合同期放疗治疗宫颈癌,疗效好,不良反应轻。
Objective To evaluate the clinical effects and adverse reactions of low-dose platinum-based chemoradiotherapy with simultaneous radiotherapy for cervical cancer. Methods Eighty-two patients with cervical cancer who were treated from September 2008 to May 2011 were enrolled in this study. Chemotherapy was given nedaplatin or cisplatin 20mg / m2 once a week for the same period combined with conventional radiotherapy and post-treatment. The total dose of radiotherapy Is 8000 ~ 8500c Gy. The results of the recent efficiency of 100%, 1, 2, 3-year survival rates were 90.2%, 78.3% and 76.3%. Late radiation damage is mainly manifested as radiation proctitis and radiation cystitis, were cured or improved after active treatment. Conclusion Low-dose platinum chemotherapy combined with concurrent radiotherapy for cervical cancer has good curative effect and mild adverse reactions.