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恩医科大学第二临床学院） 摘要目的：探讨血清白介素８（ＩＬ－８）、白介素１０（ＩＬ－１０）在支气管哮喘（ＢＡ）发病中的作用、变化规律及临床意义。方法：应用双抗夹心法检测了哮喘患者血清ＩＬ－８、ＩＬ－１０水平。结果：哮喘发作期血清 ＩＬ－８水平明显高于缓解期及正常对照组（ Ｐ＜０． ０５），发作期 ＩＬ－１０水平明显低于正常对照组（ Ｐ ＜０. ０５），缓解期升至正常水平（Ｐ＞０． ０５）。结论：ＩＬ－８、ＩＬ－１０参与了哮喘的发病，可作为临床诊断哮喘、评价哮喘严重程度及疗效的指标。
Second Affiliated Hospital of Soochow University) Abstract Objective: To investigate the role of serum interleukin 8 (IL-8) and interleukin-10 (IL-10) in the pathogenesis of bronchial asthma (BA) and their clinical significance. Methods: Serum levels of IL-8 and IL-10 in asthmatic patients were detected by double-antibody sandwich method. Results: The level of IL-8 in asthma attack group was significantly higher than that in remission and normal control group (P <0.05). IL-10 level in attack stage was significantly lower than that in control group (P <0.05) To normal (P> 0.05). Conclusion: IL-8 and IL-10 are involved in the pathogenesis of asthma, which can be used as an index to diagnose asthma, evaluate the severity and efficacy of asthma.