目的观察双歧三联活菌胶囊联合还原型谷胱甘肽注射剂对原发性肝癌患者化疗栓塞术后肝功能、内毒素和肠道菌群的影响。方法将88例原发性肝癌患者分为对照组42例和试验组46例。2组患者均给予化疗栓塞的基础治疗。术后,对照组予以静脉滴注还原型谷胱甘肽1.8 g qd;试验组在对照组治疗的基础上,予以口服双歧三联活菌胶囊每次0.42 g tid。2组患者均治疗2周。比较2组患者手术前后的肝功能、内毒素和肠道菌群水平,以及药物不良反应的发生情况。结果术后,试验组和对照组的谷丙转氨酶分别为(96.12±7.56),(147.42±8.23)U·L~(-1);谷草转氨酶分别为(90.45±8.43),(163.90±9.58)U·L~(-1);总胆红素分别为(23.96±4.12),(27.46±5.17)μmol·L~(-1);内毒素分别为(97.15±8.44),(164.53±10.74)ng·L~(-1),差异均有统计学意义(P<0.05)。术后,试验组和对照组的粪便中大肠埃希菌含量分别为(7.85±1.06),(8.43±1.40)Lg·g~(-1);双歧杆菌含量分别为(7.28±0.36),(6.41±0.43)Lg·g~(-1);乳杆菌含量分别为(7.02±0.34),(6.18±0.32)Lg·g~(-1),差异均有统计学意义(P<0.05)。2组患者发生的药物不良反应主要有胃肠道反应和皮疹,且试验组和对照组的药物不良反应发生率分别为4.35%和7.14%,差异无统计学意义(P>0.05)。结论双歧三联活菌胶囊联合还原型谷胱甘肽注射剂可以明显改善原发性肝癌患者化疗栓塞术后的肝功能,避免内毒素水平异常升高,并可有效地调节肠道菌群。 Objective To observe the effect of bifid triple viable capsule combined with reduced glutathione injection on liver function, endotoxin and intestinal microflora in patients with primary liver cancer after chemoembolization. Methods Eighty-eight patients with primary liver cancer were divided into control group (n = 42) and experimental group (n = 46). Both groups were given basic treatment of chemoembolization. After the operation, the control group was given intravenous drip of reduced glutathione 1.8 g qd; on the basis of the treatment of the control group, the experimental group was given oral bifidobacterium triple viable capsules 0.42 g tid. Two groups of patients were treated for 2 weeks. The liver function, endotoxin and intestinal microflora of the two groups before and after operation were compared, and the occurrence of adverse drug reactions were compared. Results After the operation, the alanine aminotransferases in the test group and the control group were (96.12 ± 7.56) and (147.42 ± 8.23) U · L -1, respectively. The levels of aspartate aminotransferase were (90.45 ± 8.43) and (163.90 ± 9.58) U · L -1 and total bilirubin were (23.96 ± 4.12) and (27.46 ± 5.17) μmol·L -1, respectively. Endotoxins were (97.15 ± 8.44) and (164.53 ± 10.74) ng · L ~ (-1), the difference was statistically significant (P <0.05). The levels of Escherichia coli in the feces of the experimental group and the control group were (7.85 ± 1.06) and (8.43 ± 1.40) Lg · g -1, respectively. The contents of Bifidobacterium were (7.28 ± 0.36) and (6.41 ± 0.43) Lg · g -1 and Lactobacillus were (7.02 ± 0.34) and (6.18 ± 0.32) Lg · g -1, respectively, with statistical significance (P0.05) . Adverse reactions to the two groups of patients were mainly gastrointestinal reactions and skin rashes, and the incidences of adverse drug reactions in the two groups were 4.35% and 7.14%, respectively, with no significant difference (P> 0.05). Conclusion Bifid triple viable capsule combined with reduced glutathione injection can significantly improve the liver function of patients with primary liver cancer after chemoembolization, to avoid abnormally elevated endotoxin levels, and can effectively regulate the intestinal flora.