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目的探讨应用γ-干扰素(IFN-γ)辅助治疗结核性胸膜炎患者的疗效并研究NKT细胞表达情况及意义。方法纳入本研究的71例结核性胸膜炎患者随机分成两组(甲组和乙组),甲组采用常规四联抗结核治疗方案,乙组在常规疗法基础上加用重组IFN-γ治疗,另选取31例健康体检人员作为正常对照组(丙组),并通过流式细胞术检测患者与正常对照组NKT的细胞表达,以SPSS19.0统计学软件分析上述指标之间的差异。结果乙组疗效优于甲组,差异有统计学意义(P<0.05)。结核性胸膜炎患者血液和胸腔积液中NKT细胞表达量低于正常对照组,差异有统计学意义(P<0.05)。结论常规疗法辅助IFN-γ治疗结核性胸膜炎疗效显著,优于常规治疗方案。
Objective To investigate the curative effect of interferon-γ (IFN-γ) adjuvant therapy on patients with tuberculous pleurisy and to study the expression and significance of NKT cells. Methods Totally 71 patients with tuberculous pleurisy included in this study were randomly divided into two groups (Group A and Group B). Group A received conventional quadruple anti-TB treatment. Group B received recombinant IFN-γ on the basis of conventional therapy. Twenty-one healthy volunteers were selected as normal control group (group C). The expression of NKT in patients and normal control group was detected by flow cytometry. SPSS19.0 software was used to analyze the differences among the above indexes. Results The efficacy of group B was better than group A, the difference was statistically significant (P <0.05). The expression of NKT cells in blood and pleural effusion of tuberculous pleurisy patients was lower than that of the normal control group (P <0.05). Conclusion Conventional therapy adjuvant IFN-γ treatment of tuberculous pleurisy significant effect, superior to conventional treatment.