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目的:探讨胱抑素C(Cys-C)含量与冠心病(CHD)患者可诱导性缺血发生关系。方法:检测899例冠心病患者血清胱抑素C含量,并在进行平板运动测验同时采集负荷超声心动图。结果:241例胱抑素C含量大于最高四分位数(>1.30mg/L)冠心病患者中38%发生诱导缺血,而胱抑素C含量低于最低四分位数(<0.92mg/L)患者中诱导缺血发生率为13%。不过,这种相关性在有和无冠状动脉旁路移植术(CABG)史患者间以及在服用和未服用β-受体阻滞剂和他汀类药物患者间有所不同。无冠状动脉搭桥CABG史患者中,抑素C含量大于最高四分位数和小于最低四分位数诱导缺血发生率分别为35%和9%。而未使用β-受体阻滞剂的参与者中,胱抑素C含量大于最高四分位数和小于最低四分位数诱导缺血发生率分别为44%和7%。未使用他汀类药物冠心病患者中,含量大于最高四分位数和小于最低四分位数诱导缺血发生率分别为39%和4%。结论:胱抑素C含量升高与稳定性冠状动脉疾病患者诱导缺血独立相关。
Objective: To investigate the relationship between cystatin C (Cys-C) and inducible ischemia in patients with coronary heart disease (CHD). Methods: Serum levels of cystatin C were detected in 899 patients with coronary heart disease. Load-bearing echocardiography was also performed during the treadmill exercise test. RESULTS: Thirty-eight percent of 241 patients with cystatin C levels greater than the highest quartile (> 1.30 mg / L) had ischemia-induced ischemia with cystatin C less than the lowest quartile (<0.92 mg / L) in patients with induced ischemia was 13%. However, this correlation is different between patients with and without coronary artery bypass grafting (CABG) and with and without beta-blockers and statins. Patients without CABG at coronary artery bypass grafting had a 35% and a 9% incidence of isatin-induced C greater than the highest quartile and less than the lowest quartile, respectively. Among participants who did not use beta-blockers, cystatin C levels greater than the highest quartile and those less than the lowest quartile induced ischemic rates of 44% and 7%, respectively. Unstreated coronary heart disease patients with statins more than the highest quartile and less than the lowest quartile induced ischemia were 39% and 4%. Conclusions: Elevated levels of cystatin C are independently associated with induction of ischemia in patients with stable coronary artery disease.