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目的探讨卵巢浆液性囊腺瘤和交界性浆液性肿瘤组织中M2型丙酮酸激酶(M2-PK)和组织蛋白酶D(Cath-D)的表达水平,为肿瘤的诊断、治疗及防止复发提供指导性的意见。方法采用免疫组织化学法(SP)分别对卵巢浆液性囊腺瘤(对照组)和交界性浆液性肿瘤(观察组)组织中M2-PK、Cath-D的表达水平进行检测,对比两组M2-PK、Cath-D表达的阳性率、灵敏度、特异度。结果 M2-PK在对照组和观察组肿瘤组织表达中阳性率分别为38.00%和72.00%,Cath-D在肿瘤组织表达中阳性率分别为24.00%和66.00%,两组间相比差异有统计学意义(P<0.05);M2-PK蛋白在观察组肿瘤检测中的灵敏度和特异度分别为74.00%和61.54%,Cath-D蛋白分别为66.00%和78.57%。结论 M2-PK和Cath-D蛋白的表达对卵巢交界性浆液性肿瘤早期诊断、治疗及预后有着重要的临床价值。
Objective To investigate the expression of M2-PK and Cath-D in ovarian serous cystadenoma and borderline serous tumor and provide guidance for the diagnosis, treatment and prevention of recurrence. Sexual opinions. Methods The expression of M2-PK and Cath-D in ovarian serous cystadenoma (control group) and borderline serous tumor (observation group) were detected by immunohistochemical method (SP) -PK, Cath-D expression of the positive rate, sensitivity, specificity. Results The positive rates of M2-PK in the tumor tissues of the control group and the observation group were 38.00% and 72.00%, respectively. The positive rates of Cath-D expression in the tumor tissues were 24.00% and 66.00%, respectively (P <0.05). The sensitivity and specificity of M2-PK protein in the observation group were 74.00% and 61.54% respectively, and Cath-D protein was 66.00% and 78.57% respectively. Conclusions The expression of M2-PK and Cath-D proteins has important clinical value in the early diagnosis, treatment and prognosis of borderline serous ovarian tumors.