给大鼠以干扰素（ＩＦＮ－Ａ），卡介苗（ＢＣＧ）或两者联用，以墨汁吞噬实验和溶菌酶免疫组织化学法显示肝枯否细胞（ＫＣ），以图象分析系统测定ＫＣ的数量和面积；同时进行外周血非特异性酸性酯酶（ＡＮＡＥ）阳性淋巴细胞计数。结果显示：ＩＦＮ－Ａ、ＢＣＧ或两者联用后，使溶菌酶阳性和吞噬墨汁的ＫＣ数增多，尤以肝小叶周边带为显著；ＫＣ面积明显增大；外周血ＡＮＡＥ阳性淋巴细胞增多，尤以“弥散型”淋巴细胞增多较显著。上述作用中ＢＣＧ较ＩＦＮＡ明显，尤以两者联用的效果最强。是免疫制剂增强ＫＣ抗肝癌细胞作用有关的细胞学机制。 Rats were given interferon (IFN-A), BCG (BCG), or a combination of both in ink phagocytosis test and lysozyme immunohistochemistry showed hepatic Kupffer cells (KC), image analysis system KC Quantity and area; at the same time, peripheral blood non-specific acid esterase (ANAE) positive lymphocyte count. The results showed that the combination of IFN-α, BCG, or both increased the number of lysozyme-positive and KC of phagocytizing ink, especially in the vicinity of the hepatic lobule; the area of ​​KC increased significantly; the number of ANAE positive lymphocytes in peripheral blood increased, Especially “diffuse” lymphocytes increased more significant. The role of BCG than IFNA obvious, especially the combination of the two strongest. Is the immune agent to enhance the role of KC anti-hepatocellular carcinoma-related cytological mechanisms.